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Abstract Title:

In vitro anti-HIV activity of oleanolic acid on infected human mononuclear cells.

Abstract Source:

Planta Med. 2002 Feb;68(2):111-4. PMID: 11859458

Abstract Author(s):

Fabio Mengoni, Miriam Lichtner, Lucia Battinelli, Monica Marzi, Claudio Maria Mastroianni, Vincenzo Vullo, Gabriela Mazzanti

Article Affiliation:

Department of Infectious and Tropical Diseases, University "La Sapienza", Rome, Italy.

Abstract:

Oleanolic acid is a triterpenoid which is quite common in nature in the form either of free acid or in triterpenoid saponin glycosides. This study describes the effect of oleanolic acid on the growth of human immunodeficiency virus-1 (HIV-1) in cultures of human peripheral mononuclear cells (PBMC) and of monocyte/macrophages (M/M). Its inhibitory activity was also evaluated on PBMC obtained from HIV-1 infected patients. Results obtained show that oleanolic acid inhibits the HIV-1 replication in all the cellular systems used (EC50 values: 22.7 microM, 24.6 microM and 57.4 microM for in vitro infected PBMC, naturally infected PBMC and M/M, respectively). As regards the mechanism of action, oleanolic acid inhibits in vitro the HIV-1 protease activity.

Study Type : In Vitro Study

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Sayer Ji
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