Oleuropein ameliorates advanced stage of type 2 diabetes. - GreenMedInfo Summary
Oleuropein Ameliorates Advanced Stage of Type 2 Diabetes in/Mice by Regulating Gut Microbiota.
Nutrients. 2021 Jun 22 ;13(7). Epub 2021 Jun 22. PMID: 34206641
Previous studies have reported the therapeutic effects of oleuropein (OP) consumption on the early stage of type 2 diabetes. However, the efficacy of OP on the advanced stage of type 2 diabetes has not been investigated, and the relationship between OP and intestinal flora has not been studied. Therefore, in this study, to explore the relieving effects of OP intake on the advanced stage of type 2 diabetes and the regulatory effects of OP on intestinal microbes, diabetic/mice (17-week-old) were treated with OP at the dose of 200 mg/kg for 15 weeks. We found that OP has a significant effect in decreasing fasting blood glucose levels, improving glucose tolerance, lowering the homeostasis model assessment-insulin resistance index, restoring histopathological features of tissues, and promoting hepatic protein kinase B activation in/mice. Notably, OP modulates gut microbiota at phylum level, increases the relative abundance ofand, and decreases the relative abundance of Bacteroidetes. OP treatment increases the relative abundance of, as well as decreases the relative abundance of,,, andat genus level. In conclusion, OP may ameliorate the advanced stage of type 2 diabetes through modulating the composition and function of gut microbiota. Our findings provide a promising therapeutic approach for the treatment of advanced stage type 2 diabetes.