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Abstract Title:

The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV).

Abstract Source:

Antiviral Res. 2005 Jun;66(2-3):129-36. Epub 2005 Apr 18. PMID: 15869811

Abstract Author(s):

Vicente Micol, Nuria Caturla, Laura Pérez-Fons, Vicente Más, Luis Pérez, Amparo Estepa

Abstract:

A commercial plant extract derived from olive tree leaf (Olea europaea) (LExt) and its major compound, oleuropein (Ole), inhibited the in vitro infectivity of the viral haemorrhagic septicaemia virus (VHSV), a salmonid rhabdovirus. Incubation of virus with LExt or Ole before infection reduced the viral infectivity to 10 and 30%, respectively. Furthermore, LExt drastically decreased VHSV titers and viral protein accumulation (virucidal effect) in a dose dependent manner when added to cell monolayers 36 h post-infection. On the other hand, both the LExt and Ole were able to inhibit cell-to-cell membrane fusion induced by VHSV in uninfected cells, suggesting interactions with viral envelope. Therefore, we propose that O. europaea could be used as a potential source of promising natural antivirals, which have demonstrated to lack impact on health and environment. In addition, Ole could be used to design other related antiviral agents.

Study Type : In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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