Article Publish Status: FREE
Abstract Title:

Omega-3 Fatty Acids Modulate TRPV4 Function through Plasma Membrane Remodeling.

Abstract Source:

Cell Rep. 2017 Oct 3 ;21(1):246-258. PMID: 28978477

Abstract Author(s):

Rebeca Caires, Francisco J Sierra-Valdez, Jonathan R M Millet, Joshua D Herwig, Esra Roan, Valeria Vásquez, Julio F Cordero-Morales

Article Affiliation:

Rebeca Caires


Dietary consumption ofω-3 polyunsaturated fatty acids (PUFAs), present in fish oils, is known to improve the vascular response, but their molecular targets remain largely unknown. Activation of the TRPV4 channel has been implicated in endothelium-dependent vasorelaxation. Here, we studied the contribution of ω-3 PUFAsto TRPV4 function by precisely manipulating the fatty acid content in Caenorhabditis elegans. By genetically depriving the worms of PUFAs, we determined that the metabolism of ω-3 fatty acids is required for TRPV4 activity. Functional, lipid metabolome, and biophysical analyses demonstrated that ω-3 PUFAs enhance TRPV4 function in human endothelial cells and support the hypothesis that lipid metabolism and membrane remodeling regulate cell reactivity. We propose a model whereby the eicosanoid's epoxide group location increases membrane fluidity and influences the endothelial cell response byincreasing TRPV4 channel activity. ω-3 PUFA-like molecules might be viable antihypertensive agents for targeting TRPV4 to reduce systemic blood pressure.

Study Type : Animal Study

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