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Abstract Title:

The effect of omeprazole treatment on the gut microflora and neutrophil function.

Abstract Source:

Clin Res Hepatol Gastroenterol. 2017 Mar 1. Epub 2017 Mar 1. PMID: 28258834

Abstract Author(s):

Maja Kostrzewska, Agnieszka Świdnicka-Siergiejko, Dorota Olszańska, Grażyna Jurkowska, Marzena Garley, Wioletta Ratajczak-Wrona, Ewa Jabłońska, Jacek Jamiołkowski, Andrzej Dabrowski

Article Affiliation:

Maja Kostrzewska

Abstract:

BACKGROUND AND AIM: Proton pump inhibitors (PPIs) may increase the risk of Clostridium difficile infections. There are interactions between gut microbiota and innate immune cells including neutrophils. We evaluated the effect of treatment with omeprazole on the gut microflora and neutrophil function.

METHODS: In 50 patients, we evaluated the effect of 4-week omeprazole treatment (n=25 with 20mg per day and n=25 with 20mg twice daily) on intragastric pH, results of stool culture and lactulose hydrogen breath test (LHBT) and neutrophil function.

RESULTS: The treatment caused significant increase of the mean intragastric pH, especially in the group with 20mg omeprazole twice daily (from 2.05±0.59 to 5.06±1.6, P<0.001). In LHBT, the increase of hydrogen concentration was observed in higher percentage of patients with 20mg of omeprazole twice daily, compared to patients with the lower dose (42.1% vs 29.4%; ns). Four weeks of omeprazole treatment have caused considerable changes in stool culture results. Patients treated with higher dose of omeprazole have had some tendency to decrease diversity of colonic microflora in comparison with patients treated with the lower dose of omeprazole. Treatment with omeprazole did not result in C. difficile positive stool culture and had no significant effect on neutrophil function.

CONCLUSIONS: Omeprazole treatment have caused considerable changes in stool culture results. Patients treated with the higher dose had some tendency to decreased diversity of colonic microflora and towards changes in fermenting bacteria of the gut. The potential effect of omeprazole on gut microflora does not depend on neutrophil function deterioration.

Study Type : Human Study

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Sayer Ji
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