Abstract Title:

One stressful event blocks multiple actions of diazepam for up to at least a month.

Abstract Source:

Brain Res. 1988 Apr 5 ;445(2):380-5. PMID: 3370472

Abstract Author(s):

S M Antelman, S Knopf, D Kocan, D J Edwards, J C Ritchie, C B Nemeroff

Article Affiliation:

S M Antelman


Based on recent findings of this laboratory, the hypothesis was tested that a single stressful encounter might have a persistent antidiazepam influence. Our results indicate that one exposure to a brief stressful event up to at least one month earlier prevented completely the effect of diazepam on pentylenetetrazole-induced changes in dopamine in the rat frontal cortex, elevations of plasma corticosterone levels and seizures.

Study Type : Animal Study

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