Abstract Title:

Evaluation of putative cytotoxic activity of crude extracts from Onopordum acanthium leaves and Spartium junceum flowers against the U-373 glioblastoma cell line.

Abstract Source:

Pak J Pharm Sci. 2015 Jul ;28(4):1225-32. PMID: 26142501

Abstract Author(s):

Yousef Abdel-Kareem Abusamra, Michele Scuruchi, Sofiane Habibatni, Zenib Maammeri, Samir Benayache, Angela D'Ascola, Angela Avenoso, Giuseppe Maurizio Campo, Edoardo Spina

Article Affiliation:

Yousef Abdel-Kareem Abusamra


Crude hydromethanolic (80% methanol) extracts produced by maceration of Onopordum acanthium leaves and Spartium junceum flowers were tested for cytotoxic effects against glioblastoma U-373 tumour cells. Onopordum acanthium extract was found to be ~5 times more cytotoxic than Spartium junceum (IC50 values of 309 and 1602μg/ml, respectively). Similar to most chemotherapeutic agents killing through the intrinsic pathway, Onopordum killed the cells via apoptosis, which was confirmed by the activation of caspase-3. Spartium exerted its weak cytotoxic effect, presumably by a caspase-independent, non-apoptotic form of necrotic-like programmed cell death. Onopordum acanthium is considered a promising plant for the researchers investigating putative biological activities, particularly antitumour and immune-related activity.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Apoptotic : CK(6986) : AC(5304)

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