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Article Publish Status: FREE
Abstract Title:

Green tea catechins are potent anti-oxidants that ameliorate sodium iodate-induced retinal degeneration in rats.

Abstract Source:

Sci Rep. 2016 ;6:29546. Epub 2016 Jul 7. PMID: 27383468

Abstract Author(s):

Yaping Yang, Yong Jie Qin, Yolanda W Y Yip, Kwok Ping Chan, Kai On Chu, Wai Kit Chu, Tsz Kin Ng, Chi Pui Pang, Sun On Chan

Article Affiliation:

Yaping Yang

Abstract:

Green tea extracts exhibit anti-oxidative and anti-inflammatory actions in different disease conditions. We hypothesized that green tea extract and its catechin constituents ameliorate sodium iodate-induced retinal degeneration in rats by counteracting oxidative stress. In this study, adult Sprague-Dawley rats were intravenously injected with a single dose of sodium iodate. Green tea extract (GTE; Theaphenon-E) or combinations of its catechin constituents, including (-)-epigallocatechin gallate (EGCG), were administered intra-gastrically before injection. Live imaging analysis using confocal scanning laser ophthalmoscopy and spectral-domain optical coherence tomography showed a progressive increase of degenerating profile across the retinal surface and decrease in thickness of outer nuclear layer (ONL) at Day-14 of post-injection. These lesions were significantly ameliorated by Theaphenon-E and catechin combinations with EGCG. Catechins with exclusion of EGCG did not show obvious protective effect. Histological analyses confirmed that Theaphenon-E and catechins containing EGCG protect the retina by reducing ONL disruption. Retinal protective effects were associated with reduced expression of superoxide dismutase, glutathione peroxidase and caspase-3, and suppression of 8-iso-Prostaglandin F2α generation in the retina. In summary, GTE and its catechin constituents are potent anti-oxidants that offer neuroprotection to the outer retinal degeneration after sodium iodate insult, among which EGCG is the most active constituent.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
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