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Article Publish Status: FREE
Abstract Title:

Oral Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 to reduce Group B Streptococcus colonization in pregnant women: A randomized controlled trial.

Abstract Source:

Taiwan J Obstet Gynecol. 2016 Aug ;55(4):515-8. PMID: 27590374

Abstract Author(s):

Ming Ho, Yin-Yi Chang, Wei-Chun Chang, Hung-Chih Lin, Mei-Hung Wang, Wu-Chou Lin, Tsan-Hung Chiu

Article Affiliation:

Ming Ho

Abstract:

OBJECTIVE: This study is to examine the effect of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 taken orally before bedtime on Group B Streptococcus (GBS)-positive pregnant women with respect to becoming GBS negative.

MATERIALS AND METHODS: In total, 110 pregnant women at 35-37 weeks of gestation who were diagnosed by GBS culture as being GBS positive for both vaginal and rectal GBS colonization were randomly assigned to be orally treated with two placebo capsules or two probiotic capsules (containing L. rhamnosus GR-1 and L. reuteri RC-14) before bedtime until delivery. All women were tested for vaginal and rectal GBS colonization again by GBS culture on admission for delivery.

RESULTS: Of the 110 participants, 99 completed the study (49 in the probiotic group and 50 in the placebo group). The GBS colonization results changed from positive to negative in 21 women in the probiotic group (42.9%) and in nine women in the placebo group (18.0%) during this period (Chi-square p=0.007).

CONCLUSION: Oral probiotic containing L. rhamnosus GR-1 and L. reuteri RC-14 could reduce the vaginal and rectal GBS colonization rate in pregnant women.

Study Type : Human Study

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