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Article Publish Status: FREE
Abstract Title:

Oral administration of fisetin promotes the induction of hippocampal long-term potentiation in vivo.

Abstract Source:

J Pharmacol Sci. 2018 Jan ;136(1):42-45. Epub 2017 Dec 20. PMID: 29317180

Abstract Author(s):

Wen-Bin He, Kazuho Abe, Tatsuhiro Akaishi

Article Affiliation:

Wen-Bin He

Abstract:

To explore memory enhancing effect of the flavonoid fisetin, we investigated the effect of oral administration of flavonoids on the induction of long-term potentiation (LTP) at hippocampal CA1 synapses of anesthetized rats. Among four flavonoids (fisetin, quercetin, luteolin and myricetin) tested, only fisetin significantly facilitated the induction of hippocampal LTP. The effect of oral fisetin was abolished by intracerebroventricular injection of U0126, an agent that was previously found to inhibit its effect in hippocampal slices in vitro. These results suggest that orally administered fisetin crosses the blood-brain barrier and promotes synaptic functions in the hippocampus.

Study Type : Animal Study
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