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Article Publish Status: FREE
Abstract Title:

Oridonin prevents insulin resistance-mediated cognitive disorder through PTEN/Akt pathway and autophagy in minimal hepatic encephalopathy.

Abstract Source:

J Cell Mol Med. 2020 01 ;24(1):61-78. Epub 2019 Sep 30. PMID: 31568638

Abstract Author(s):

Fangfang Wen, Weishan Zhuge, Jian Wang, Xiaoai Lu, Ruimin You, Leping Liu, Qichuan Zhuge, Saidan Ding

Article Affiliation:

Fangfang Wen

Abstract:

Minimal hepatic encephalopathy (MHE) was characterized for cognitive dysfunction. Insulin resistance (IR) has been identified to be correlated with the pathogenesis of MHE. Oridonin (Ori) is an active terpenoid, which has been reported to rescue synaptic loss and restore insulin sensitivity. In this study, we found that intraperitoneal injection of Ori rescued IR, reduced the autophagosome formation and synaptic loss and improved cognitive dysfunction in MHE rats. Moreover, in insulin-resistant PC12 cells and N2a cells, we found that Ori blocked IR-induced synaptic deficits via the down-regulation of PTEN, the phosphorylation of Akt and the inhibition of autophagy. Taken together, these results suggested that Ori displays therapeutic efficacy towards memory deficits via improvement of IR in MHE and represents a novel bioactive therapeutic agent for treating MHE.

Study Type : In Vitro Study

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