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Article Publish Status: FREE
Abstract Title:

Oridonin Suppresses Proliferation of Human Ovarian Cancer Cells via Blockage of mTOR Signaling.

Abstract Source:

Asian Pac J Cancer Prev. 2016 ;17(2):667-71. PMID: 26925661

Abstract Author(s):

Rong Xia, Sun-Xiao Chen, Qin Qin, Yan Chen, Wei-Wei Zhang, Rong-Rong Zhu, An-Mei Deng

Article Affiliation:

Rong Xia

Abstract:

Oridonin, an ent-kaurane diterpenoid compound isolated from the traditional Chinese herb Rabdosia rubescens, has shown various pharmacological and physiological effects such as anti-tumor, anti-bacterial, and anti-inflammatory properties. However, the effect of oridonin on human ovarian cancer cell lines has not been determined. In this study, we demonstrated that oridonin inhibited ovarian cancer cell proliferation, migration and invasion in a dose-dependent manner. Furthermore, we showed oridonin inhibited tumor growth of ovarian cancer cells (SKOV3) in vivo. We then assessed mechanisms and found that oridonin specifically abrogated the phosphorylation/activation of mTOR signaling. In summary, our results indicate that oridonin is a potential inhibitor of ovarian cancer by blocking the mTOR signaling pathway.

Study Type : In Vitro Study

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