Origanum vulgare L. essential oil inhibits the growth of carbapenem-resistant gram-negative bacteria.
Rev Soc Bras Med Trop. 2019 Jun 27 ;52:e20180502. Epub 2019 Jun 27. PMID: 31271619
Nathalie Gaebler Vasconcelos
INTRODUCTION: Plant products are sources for drug development against multidrug resistant bacteria.
METHODS: The antimicrobial activity of Origanum vulgare L. essential oil (OVeo) against carbapenem-resistant strains was assessed by disk-diffusion, microdilution (REMA-Resazurin Microtiter Assay), and time kill assays.
RESULTS: Carbapenemase production was confirmed for all strains. OVeo exhibited a minimum inhibitory concentration of 0.059% v/v for Klebsiella pneumoniae and Serratia marcescens, and of 0.015 % v/v for Acinetobacter baumannii. A decrease in cell count was observed after a 4 h treatment.
CONCLUSIONS: OVeo antimicrobial effect was rapid and consistent, making it a candidate for developing alternative therapeutic options against carbapenem-resistant strains.