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Article Publish Status: FREE
Abstract Title:

Orthosiphon pallidus, a Potential Treatment for Patients with Breast Cancer.

Abstract Source:

J Pharmacopuncture. 2017 Dec ;20(4):265-273. Epub 2017 Apr 14. PMID: 30151296

Abstract Author(s):

Mukesh K Singh, Hemant Dhongade, Dulal Krishna Tripathi

Article Affiliation:

Mukesh K Singh

Abstract:

Objective: , which belongs to thefamily, is a popular garden plant that is widely used for the treatment of various diseases, such as urinary lithiasis, fever, hepatitis, cancer and jaundice. The objective of the present work was to investigate the antioxidant free-radical scavenging and the anticancer activities ofagainst human breast-cancer cell lines.

Methods: The antioxidant activity ofaqueous extract (OPAE) was investigated using different models, such as the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the 2, 2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) models, as were the Fechelation, the hydroxyl radical and superoxide radical scavenging, and total reducing power activities. The anticancer activities of the extract were determined by using the 3-(4, 5- dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) and the sulforhodamine (SRB) assays on the MCF-7 and the MDA-MB-231 cancer cell lines.

Results: The aqueousextract showed potent activity inmodels. It significantly inhibited the scavenging of hydroxyl and superoxide radicals, but induced a remarkable Fechelation activity. For both cell lines, the percent cytotoxicity was found to increase steadily with increasing OPAE concentration up to 240μg/mL.

Conclusion: These results suggest thathas excellent antioxidant, antimicrobial, and anticancer activities against human breast-cancer cell lines.

Study Type : In Vitro Study

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Sayer Ji
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