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Abstract Title:

Otoprotective Effects ofα-lipoic Acid on A/J Mice With Age-related Hearing Loss.

Abstract Source:

Otol Neurotol. 2020 Jul ;41(6):e648-e654. PMID: 32282782

Abstract Author(s):

Shanshan Huang, Ang Xu, Xiumei Sun, Wenjing Shang, Bingxin Zhou, Yi Xie, Mengmeng Zhao, Ping Li, Peng Lu, Tingyan Liu, Fengchan Han

Article Affiliation:

Shanshan Huang

Abstract:

OBJECTIVE: A/J mice are a mouse model of age-related hearing loss (AHL) with progressive degeneration of outer hair cells (OHCs), spiral ganglion neurons (SGNs), and stria vascularis. This study was carried out to observe the otoprotective effects ofα-lipoic acid on A/J mice.

METHODS: A/J mouse pups at postnatal day 7 were randomly distributed into the untreated group, the dimethyl sulfoxide (DMSO) group, and theα-lipoic acid + DMSO group. α-lipoic acid was given to the mice intraperitoneally at a dosage of 50 μg/g body weight every other day. Time course auditory-evoked brainstem response (ABR) thresholds were tested. OHC loss was counted and the densities of SGNs and the width of stria vasculariswere measured at 4 and 8 weeks of age.

RESULTS: Measurement of the ABR thresholds revealed that hearing loss in A/J mice was attenuated byα-lipoic acid at age from 3 to 8 weeks. Moreover, preservation effects of OHCs, SGNs, and stria vascularis by α-lipoic acid were observed in the cochleae of A/J mice at 4 and 8 weeks of age.

CONCLUSION: Hearing loss in A/J mice can be attenuated byα-lipoic acid. The otoprotective effects of α-lipoic acid on A/J mice may be obtained by preserving OHCs, SGNs, and stria vascularis in the cochleae. The oxidative damage related to gene mutations may be a potential target for AHL prevention and therapy.

Study Type : Animal Study

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