Abstract Title:

Thrombocytopenia after vaccination: case reports to the US Vaccine Adverse Event Reporting System, 1990-2008.

Abstract Source:

Vaccine. 2010 Nov 29. Epub 2010 Nov 29. PMID: 21126606

Abstract Author(s):

Emily Jane Woo, Robert P Wise, David Menschik, Sean V Shadomy, John Iskander, Judy Beeler, Frederick Varricchio, Robert Ball

Article Affiliation:

Food and Drug Administration HFM-222, FDA/CBER/OBE, 1401 Rockville Pike, Rockville, MD 20852, United States.

Abstract:

We reviewed thrombocytopenia (TP) reports to the US Vaccine Adverse Event Reporting System (VAERS). We examined TP patterns for differences in single versus multiple immunization reports, presence of a live viral vaccine, seriousness, age, and interval to symptom onset. We found 1510 reports of possible TP and after exclusions evaluated 1440 for possible causes. Most (1078; 75%) met the regulatory definition of a serious adverse event. TP was reported after inactivated and live viral vaccines. Platelet counts<10×10(9)/L were reported. Identified vaccines could be prioritized for hypothesis-testing studies.

Study Type : Meta Analysis

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Sayer Ji
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