Abstract Title:

Oxazole-Containing Diterpenoids from Cell Cultures of Salvia miltiorrhiza and Their Anti-HIV-1 Activities.

Abstract Source:

J Nat Prod. 2017 Dec 22 ;80(12):3241-3246. Epub 2017 Nov 29. PMID: 29185738

Abstract Author(s):

Dewu Zhang, Jiamei Guo, Min Zhang, Xiao Liu, Mingyu Ba, Xiaoyu Tao, Liyan Yu, Ying Guo, Jungui Dai

Article Affiliation:

Dewu Zhang


Four new oxazole-containing diterpenoids, salvianans A-D (1-4), along with three known diterpenoids (5-7), were isolated from Salvia miltiorrhiza cell cultures. The structures of the new compounds were elucidated using spectroscopic methods and single-crystal X-ray diffraction. The evaluation for their anti-HIV-1 activities revealed that 2 and 3 displayed inhibitory activities with ICvalues of 0.03 and 1.2μM, respectively. The time of addition (TOA) assay and long terminal repeat (LTR) luciferase reporter assay results indicated that compound 2 was an HIV-1 transcription inhibitor and might be a lead compound of antiviral agents acting on HIV-1 transcription.

Study Type : In Vitro Study

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