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Abstract Title:

Investigation of the immunostimulatory properties of oxihumate.

Abstract Source:

Z Naturforsch C. 2003 Mar-Apr;58(3-4):263-7. PMID: 12710739

Abstract Author(s):

Gisela Käthe Jooné, Johan Dekker, Constance Elizabeth Jansen van Rensburg

Article Affiliation:

Department of Pharmacology, Faculty of Medical Sciences, University of Pretoria, PO Box 2034, Pretoria, 0001, South Africa. cmedlen@postillion.up.ac.za

Abstract:

A unique process has been developed to convert bituminous coal by controlled wet oxidation followed by base treatment to a water-soluble humate called oxihumate. The effects of oxihumate on the proliferative response of lymphocytes has been studied in vitro and ex vivo. Oxihumate increased the proliferative response of phytohaemagglutinin-stimulated human lymphocytes, from a concentration of 20 microg/ml and upwards. This response was even more striking in the case of lymphocytes from HIV-infected patients and was not limited to the in vitro setting since similar effects were observed ex vivo following administration of a non-toxic dosage of 4 g oxihumate per day to HIV-positive individuals for two weeks. Mechanistic studies revealed that stimulation of the proliferative response of lymphocytes by oxihumate is associated with an increased production of IL-2, as well as expression of the IL-2 receptor in the setting of decreased production of IL-10. Oxihumate therefore holds promise for the treatment of immunocompromized patients.

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Sayer Ji
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