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Abstract Title:

Anti-Inflammatory Effects of p-Coumaric Acid, a Natural Compound of, on Arthritis Model Rats.

Abstract Source:

Evid Based Complement Alternat Med. 2018 ;2018:5198594. Epub 2018 Feb 22. PMID: 29681976

Abstract Author(s):

Hao Zhu, Qing-Hua Liang, Xin-Gui Xiong, Yang Wang, Zhi-Hui Zhang, Mei-Juan Sun, Xun Lu, Dan Wu

Article Affiliation:

Hao Zhu

Abstract:

Objectives: In China,(OD) is a natural herb that is widely used and has been proven to be effective in the treatment of rheumatoid arthritis (RA). This study aimed to preliminarily reveal the mechanism by which OD exerts its beneficial effect.

Methods: Ultra-performance liquid chromatography photodiode array was applied to identify the absorbable compounds in the plasma of collagen-induced arthritis (CIA) model rats. After 2 weeks, an OD decoction or the identified absorbable compound was administered to CIA rats. Morphology, X-ray images of the joints, pathological images, arthritis index, and cytokine (TNF-and IL-6) levels were evaluated.

Results: p-Coumaric acid (p-CA) was identified as the absorbed compound in plasma. After administration of p-CA solution or the OD decoction, symptoms in the treated rats were alleviated as compared to the untreated model rats, and inflammatory cell infiltration was suppressed. The arthritis index and serum levels of TNF-and IL-6 were decreased as compared to the control group.

Conclusions: OD may exert its anti-inflammatory effect on RA via its active ingredient, p-CA. This information sheds light on the mechanism by which OD exerts its anti-inflammatory effort in RA and forms the basis for further development of therapeutic agents for RA.

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