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Abstract Title:

Evaluation of cytotoxic, immunomodulatory effects, antimicrobial activities and phytochemical constituents from various extracts of(Passifloraceae).

Abstract Source:

Nat Prod Res. 2020 Aug 7:1-5. Epub 2020 Aug 7. PMID: 32762448

Abstract Author(s):

Georon Ferreira de Sousa, Dayane Kelly Dias do Nascimento Santos, Ricardo Sérgio da Silva, Bárbara Rafaela da Silva Barros, Iranildo José da Cruz-Filho, Bárbara de Azevedo Ramos, Túlio Diego da Silva, Pérsio Alexandre da Silva, Reginaldo Gonçalves de Lima-Neto, Norma Buarque de Gusmão, Marcia Silva do Nascimento, Cristiane Moutinho Lagos de Melo

Article Affiliation:

Georon Ferreira de Sousa

Abstract:

The leaves ofwere subjected to physicochemical analysis, such as ion content, extractives, and structural molecules. The hexanic, ethanolic and ethyl acetate extracts were submitted to phytochemical analyzes by GC-MS, HPLC-MS, and spectrophotometry. In addition, antioxidant (DPPH, ABTS and TAA methods) potential, antimicrobial (MIC method) action, cytotoxicity and immunostimulant activity (flow cytometry analysis) were performed. The extracts showed a moderate antioxidant capacity and revealed the presence of several metabolites, mainly phenols, such as caffeic acid, p-coumaric acid and luteolin. The ethyl acetate and ethanolic extracts showed antifungal activity. In addition, the extracts did not affect splenocytes viability at 12.5 μg/mL and promoted the production of IL-6, IL-10, IL-17 and TNF-α cytokines.extracts showed antifungal and antioxidant activity and were able to induce immunostimulatory action in splenocyte cultures.

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