Abstract Title:

Evaluation of cytotoxic, immunomodulatory effects, antimicrobial activities and phytochemical constituents from various extracts of(Passifloraceae).

Abstract Source:

Nat Prod Res. 2020 Aug 7:1-5. Epub 2020 Aug 7. PMID: 32762448

Abstract Author(s):

Georon Ferreira de Sousa, Dayane Kelly Dias do Nascimento Santos, Ricardo Sérgio da Silva, Bárbara Rafaela da Silva Barros, Iranildo José da Cruz-Filho, Bárbara de Azevedo Ramos, Túlio Diego da Silva, Pérsio Alexandre da Silva, Reginaldo Gonçalves de Lima-Neto, Norma Buarque de Gusmão, Marcia Silva do Nascimento, Cristiane Moutinho Lagos de Melo

Article Affiliation:

Georon Ferreira de Sousa


The leaves ofwere subjected to physicochemical analysis, such as ion content, extractives, and structural molecules. The hexanic, ethanolic and ethyl acetate extracts were submitted to phytochemical analyzes by GC-MS, HPLC-MS, and spectrophotometry. In addition, antioxidant (DPPH, ABTS and TAA methods) potential, antimicrobial (MIC method) action, cytotoxicity and immunostimulant activity (flow cytometry analysis) were performed. The extracts showed a moderate antioxidant capacity and revealed the presence of several metabolites, mainly phenols, such as caffeic acid, p-coumaric acid and luteolin. The ethyl acetate and ethanolic extracts showed antifungal activity. In addition, the extracts did not affect splenocytes viability at 12.5 μg/mL and promoted the production of IL-6, IL-10, IL-17 and TNF-α cytokines.extracts showed antifungal and antioxidant activity and were able to induce immunostimulatory action in splenocyte cultures.

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