Profiling the phyto-constituents offruits peel extract and accessing itsantioxidant, anti-diabetic, anti-obesity, and angiotensin-converting enzyme inhibitory properties.
Saudi J Biol Sci. 2020 Dec ;27(12):3228-3234. Epub 2020 Oct 6. PMID: 33304128
This context was investigated to assess theantioxidant, anti-diabetic, anti-obesity, and angiotensin-converting enzyme (ACE) inhibition traits offruits peel extract. Initially, among various extracts tested, aqueous and ethanolic peel extracts depicted the presence of diverse phytoconstituents.antioxidative properties of peel extracts were determined using standard methodologies. Results showed that aqueous and ethanolic extracts had ICvalues of 471.7 and 509.16 μg/mL, respectively in terms of 1,1,diphenyl 2,2,picrylhydrazyl scavenging. Likewise, ICvalues of aqueous and ethanol extract were obtained as 488.76 and 478.47 μg/mL towards the degradation of hydrogen peroxide. The ethanolic extract exhibited the highest inhibition of αglucosidase by showing activity of 53.34 ± 2.0 to 15.18 ± 1.4 U/L in a dose dependent manner (100-1000 µg/mL). Ethanolic extract was reported as the most active inhibitor of lipase with an ICvalue of 603.50 µg/mL. Ethanolic extract showed increased inhibition of ACE in a concentration dependent manner (100-1000 µg/mL) with ICvalue of 519.45 µg/mL. Fourier transform-infrared spectrum revealed the availability of various functional groups in the ethanolic extract of peel. Gas chromatography-mass spectrometry chromatogram of peel extract illustrated 23 diversified chemical constituents including 1,2,3,4-butanetetrol, Dimethyl sulfone,9-octadecenamide, and Pentadecanoic acid as predominant compounds. In summary,fruits peel extract revealed promising antioxidant, anti-diabetic, anti-obesity, and anti-hypertensive properties.