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Article Publish Status: FREE
Abstract Title:

Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke.

Abstract Source:

Evid Based Complement Alternat Med. 2016 ;2016:1698379. Epub 2016 Nov 28. PMID: 28003846

Abstract Author(s):

Jinpei Lin, Fei Xu, Genfa Wang, Lingwen Kong, Qingli Luo, Yvbao Lv, Jiaqi Liu, Ying Wei, Lulu Li, Hongying Zhang, Jingcheng Dong

Article Affiliation:

Jinpei Lin

Abstract:

Paeoniflorin (PF), a monoterpene glucoside, might have an effect on the oxidative stress. However, the mechanism is still unknown. In this study, we made the COPD model in Sprague-Dawley (SD) rats by exposing them to the smoke of 20 cigarettes for 1 hour/day and 6 days/week, for 12 weeks, 24 weeks, or 36 weeks. Our findings suggested that smoke inhalation can trigger the oxidative stress from the very beginning. A 24-week treatment of PF especially in the dosage of 40 mg/kg·d can attenuate oxygen stress by partially quenching reactive oxygen species (ROS) and upregulating antioxidant enzymes via an Nrf2-dependent mechanism.

Study Type : Animal Study

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Sayer Ji
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