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Article Publish Status: FREE
Abstract Title:

Paeonol Attenuates Quorum-Sensing Regulated Virulence and Biofilm Formation in.

Abstract Source:

Front Microbiol. 2021 ;12:692474. Epub 2021 Aug 4. PMID: 34421847

Abstract Author(s):

Dan Yang, Suqi Hao, Ling Zhao, Fei Shi, Gang Ye, Yuanfeng Zou, Xu Song, Lixia Li, Zhongqiong Yin, Xiaoli He, Shiling Feng, Helin Chen, Yu Zhang, Yuanze Gao, Yinglun Li, Huaqiao Tang

Article Affiliation:

Dan Yang

Abstract:

With the prevalence of multidrug-resistant bacteria and clinical -acquired pathogenic infections, the development of quorum-sensing (QS) interfering agents is one of the most potential strategies to combat bacterial infections and antibiotic resistance. Chinese herbal medicines constitute a valuable bank of resources for the identification of QS inhibitors. Accordingly, in this research, some compounds were tested for QS inhibition using indicator strains. Paeonol is a phenolic compound, which can effectively reduce the production of violacein without affecting its growth inATCC 12472, indicating its excellent anti-QS activity. This study assessed the anti-biofilm activity of paeonol against Gram-negative pathogens and investigated the effect of paeonol on QS-regulated virulence factors in. Ainfection model was used to explore the anti-infection ability of paeonol. Paeonol exhibited an effective anti-biofilm activity against Gram-negative bacteria. The ability of paeonol to interfere with the AHL-mediated quorum sensing systems ofwas determined, found that it could attenuate biofilm formation, and synthesis of pyocyanin, protease, elastase, motility, and AHL signaling molecule in a concentration- and time-dependent manner. Moreover, paeonol could significantly downregulate the transcription level of the QS-related genes ofincluding, as well as mediated its virulence factors,, and.studies revealed that paeonol could reduce the pathogenicity ofand enhance the survival rate of, showing a moderate protective effect on. Collectively, these findings suggest that paeonol attenuates bacterial virulence and infection ofand that further research elucidating the anti-QS mechanism of this compoundis warranted.

Study Type : In Vitro Study

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