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Abstract Title:

Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock.

Abstract Source:

Fundam Clin Pharmacol. 2014 Jun ;28(3):268-76. Epub 2013 Feb 17. PMID: 23413967

Abstract Author(s):

Na Chen, Dianfeng Liu, Lanan Wassy Soromou, Jingjing Sun, Weiting Zhong, Weixiao Guo, Meixia Huo, Hongyu Li, Shuang Guan, Zhenwen Chen, Haihua Feng

Article Affiliation:

Na Chen

Abstract:

Paeonol (2'-hydroxy-4'-methoxyacetophenone) is the main phenolic compound of the radix of Paeonia suffruticosa which has been used as traditional Chinese medicine. In this study, we primarily investigated the anti-inflammatory effects and the underlying mechanisms of paeonol in RAW macrophage cells; and based on these effects, we assessed the protective effects of paeonol on lipopolysaccharide-induced endotoxemia in mice. The in vitro study showed that paeonol regulated the production of TNF-α, IL-1β, IL-6, and IL-10 via inactivation of IκBα, ERK1/2, JNK, and p38 MAPK. In mouse model of lipopolysaccharide-induced endotoxemia, pro- and anti-inflammatory cytokines are significantly regulated, and thus the survival rates of lipolysaccharide-challenged mice are improved by paeonol (150,200, or 250 mg/kg). Therefore, paeonol has a beneficial activity against lipopolysaccharide-induced inflammation in RAW 264.7 cell and mouse models.

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