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Abstract Title:

Anthelmintic activity of papaya latex against patent Heligmosomoides polygyrus infections in mice.

Abstract Source:

J Ethnopharmacol. 1995 Nov 3;48(3):161-4. PMID: 8719976

Abstract Author(s):

F Satrija, P Nansen, S Murtini, S He

Article Affiliation:

Department of Veterinary Microbiology, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark.

Abstract:

The purpose of this experiment was to study the possible anthelmintic activity of papaya latex (Carica papaya) against Heligmosomoides polygyrus in experimentally infected mice. Five groups of BALB/C mice were infected with 100 Heligmosomoides polygyrus infective larvae/mouse. After patency (day 22) four groups of mice (groups B, C, D and E) were given papaya latex suspended in water at dose levels of 2, 4, 6 and 8 g of papaya latex/kg body weight, respectively. One group of mice (group A) served as non-treated controls. All animals were necropsied on day 25, i.e. 3 days after treatment, for post-mortem worm counts. The papaya latex showed an antiparasitic efficacy of 55.5, 60.3, 67.9 and 84.5% in groups B, C, D and E, respectively. The results may suggest a potential role of papaya latex as an anthelmintic against patent intestinal nematodes of mammalian hosts.

Study Type : Commentary

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Sayer Ji
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