Article Publish Status: FREE
Abstract Title:

Effect of Heat-killedDKGF7 on a Rat Model of Irritable Bowel Syndrome.

Abstract Source:

Nutrients. 2021 Feb 9 ;13(2). Epub 2021 Feb 9. PMID: 33572194

Abstract Author(s):

Gyeol Seong, Seungbaek Lee, Yang Won Min, Yeon Sil Jang, Hong Seog Kim, Eui-Joong Kim, So-Young Park, Cheol-Hyun Kim, Dong Kyung Chang

Article Affiliation:

Gyeol Seong


Non-viable bacteria, referred to as"paraprobiotics,"have attracted attention as potentially safer alternatives to probiotics. The aim of this study was to investigate the efficacy of heat-killedDKGF7 on the symptomatic improvement of irritable bowel syndrome (IBS) in a rat disease model and to elucidate the underlying mechanisms that contribute to the beneficial effects of heat-killed probiotics. Seven male Wistar rats were induced with IBS by restraint stress and administered heat-killedDKGF7 for four weeks and then compared with seven rats in the control group. Stool consistency measured four weeks after initial treatment was the primary outcome measure. To investigate the mechanism of action of the heat-killed bacteria on IBS, we measured serum corticosterone levels, inflammatory cytokines in colon tissue, and expression of tight junction proteins (TJPs) in the epithelium. The treatment group showed significantly better stool consistency scores than the control group at week 4, as well as at every measured time point (allvalues<0.05). The treatment group showed lower serum corticosterone levels, lower colonic inflammatory cytokine levels, and higher expression of TJPs compared with the control group. Paraprobiotics such as heat-killedDKGF7 can improve stool consistency in a rat IBS model, which may indicate a potential therapeutic strategy for IBS treatment.

Study Type : Animal Study

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