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Abstract Title:

Parthenolide attenuates cerebral ischemia/reperfusion injury via Akt/GSK-3β pathway in PC12 cells.

Abstract Source:

Biomed Pharmacother. 2017 May ;89:1159-1165. Epub 2017 Mar 24. PMID: 28314243

Abstract Author(s):

Jun-Feng Zhang, Li Zhang, Li-Li Shi, Zhao-Hua Zhao, Hao Xu, Fei Liang, Hong-Bo Li, Yan Zhao, Xi Xu, Ke Yang, Ying-Fang Tian

Article Affiliation:

Jun-Feng Zhang

Abstract:

Parthenolide (PN), a sesquiterpene lactone isolated from the herbal medicine feverfew (Tanacetum parthenium), was reported to possess neuroprotective activity. However, the neuroprotective effect of PN against cerebral ischemia/reperfusion (I/R) injury remains unclear. Therefore, the aim of the present study was to explore the neuroprotective effects of PN against oxygen-glucose deprivation (OGD)-induced apoptosis in PC12 cells and the underlying mechanisms. Our results demonstrated that PN ameliorated OGD/R-evoked neuronal injury and oxidative stress in PC12 cells. In addition, PN notably decreased HIF-1α expression, as well as inhibited apoptosis in PC12 cells after OGD/R. Furthermore, PN pretreatment significantly enhanced the phosphorylation of Akt and GSK-3β in PC12 cells exposed to OGD/R. In conclusion, the present study demonstrated that PN exhibits a neuroprotective effect against OGD/R through activation of the Akt/GSK-3β signaling pathway. Our findings suggest that PN has the potential to serve as a novel therapeutic agent for cerebral I/R injury.

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Sayer Ji
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