n/a
Abstract Title:

Parthenolide reduces metastasis by inhibition of vimentin expression and induces apoptosis by suppression elongation factorα - 1 expression.

Abstract Source:

Phytomedicine. 2018 Mar 1 ;41:67-73. Epub 2018 Jan 31. PMID: 29519321

Abstract Author(s):

Nesa Jafari, Sonbol Nazeri, Sattar Tahmasebi Enferadi

Article Affiliation:

Nesa Jafari

Abstract:

BACKGROUND: Use of pharmaceutical agent for breast cancer chemotherapy is an interesting method that induces cells death by different way, such as apoptosis. Parthenolide is the main compound in feverfew that has been used to cure migraine and rheumatoid arthritis for long time. Parthenolide has been predominately investigated as inducer of apoptosis in human cancer cells.

PURPOSE: We examined the expression of vimentin and Elongation factorα - 1 as breast cancer biomarkers in MCF7 cells exposure to Parthenolide.

METHOD: In this study, we investigated the antitumor mechanism of Parthenolide on the human breast cancer cell line MCF7, using SEM, flow cytometry and proteomics techniques.

RESULT: Comparative proteome analyses are shown Elongation factor1-α and vimentin was suppressed in response to Parthenolide treatment.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.