Parthenolide reduces metastasis by inhibition of vimentin expression and induces apoptosis by suppression elongation factorα - 1 expression.
Phytomedicine. 2018 Mar 1 ;41:67-73. Epub 2018 Jan 31. PMID: 29519321
BACKGROUND: Use of pharmaceutical agent for breast cancer chemotherapy is an interesting method that induces cells death by different way, such as apoptosis. Parthenolide is the main compound in feverfew that has been used to cure migraine and rheumatoid arthritis for long time. Parthenolide has been predominately investigated as inducer of apoptosis in human cancer cells.
PURPOSE: We examined the expression of vimentin and Elongation factorα - 1 as breast cancer biomarkers in MCF7 cells exposure to Parthenolide.
METHOD: In this study, we investigated the antitumor mechanism of Parthenolide on the human breast cancer cell line MCF7, using SEM, flow cytometry and proteomics techniques.
RESULT: Comparative proteome analyses are shown Elongation factor1-α and vimentin was suppressed in response to Parthenolide treatment.