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Abstract Title:

Parthenolide regulates oxidative stress-induced mitophagy and suppresses apoptosis through p53 signaling pathway in C2C12 myoblasts.

Abstract Source:

J Cell Biochem. 2019 Sep ;120(9):15695-15708. Epub 2019 May 29. PMID: 31144365

Abstract Author(s):

Yinghui Ren, Yan Li, Jienv Lv, Xiangdong Guo, Jieyou Zhang, Dongmei Zhou, Zimu Zhang, Zhenyi Xue, Guangze Yang, Qing Xi, Hongkun Liu, Zehan Liu, Lijuan Zhang, Qi Zhang, Zhi Yao, Rongxin Zhang, Yurong Da

Article Affiliation:

Yinghui Ren

Abstract:

Muscle redox disturbances and oxidative stress have emerged as a common pathogenetic mechanism and potential therapeutic intervention in some muscle diseases. Parthenolide (PTL), a sesquiterpene lactone found in large amounts in the leaves of feverfew, possesses anti-inflammatory, anti-migraine, and anticancer properties. Although PTL was reported to alleviate cancer cachexia and improve skeletal muscle characteristics in a cancer cachexia model, its actions on oxidative stress-induced damage in C2C12 myoblasts have not been reported and the regulatory mechanisms have not yet been defined. In our study, PTL attenuated HO-induced growth inhibition and morphological changes. Furthermore, PTL exhibited scavenging activity against reactive oxygen species and protected C2C12 cells from apoptosis in response to HO. Meanwhile, PTL suppressed collapse of the mitochondrial membrane potential, thereby contributing to normalizing HO-induced autophagy flux and mitophagy, correlating with inhibiting degradation of mitochondrial marker protein TIM23, the increase in LC3-II expression and the reduction of mitochondria DNA. Besides its protective effect on mitochondria, PTL also prevented HO-induced lysosomes damage in C2C12 cells. In addition, the phosphorylation of p53, cathepsin B, and Bax/Bcl-2 protein levels, and the translocation of Bax from the cytosol to mitochondria induced by HOin C2C12 cells was significantly reduced by PTL. In conclusion, PTL modulates oxidative stress-induced mitophagy and protects C2C12 myoblasts against apoptosis, suggesting a potential protective effect against oxidative stress-associated skeletal muscle diseases.

Study Type : In Vitro Study

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