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Abstract Title:

Passiflora edulis peel intake and ulcerative colitis: approaches for prevention and treatment.

Abstract Source:

Exp Biol Med (Maywood). 2014 May ;239(5):542-51. Epub 2014 Mar 12. PMID: 24623393

Abstract Author(s):

Cinthia Bb Cazarin, Juliana K da Silva, Talita C Colomeu, Angela G Batista, Conceição A Vilella, Anderson L Ferreira, Stanislau Bogusz Junior, Karina Fukuda, Fabio Augusto, Luciana R de Meirelles, Ricardo de L Zollner, Mário R Maróstica Junior

Article Affiliation:

Cinthia Bb Cazarin

Abstract:

Inflammatory bowel disease is a chronic relapsing disease that affects millions of people worldwide; its pathogenesis is influenced by genetic, environmental, microbiological, and immunological factors. The aim of this study was to evaluate the effects of short- and long-term Passiflora edulis peel intake on the antioxidant status, microbiota, and short-chain fatty acids formation in rats with 2,4,6-trinitrobenzenesulphonic acid-induced colitis using two"in vivo"experiments: chronic (prevention) and acute (treatment). The colitis damage score was determined using macroscopic and microscopic analyses. In addition, the antioxidant activity in serum and other tissues (liver and colon) was evaluated. Bifidobacteria, lactobacilli, aerobic bacteria and enterobacteria, and the amount of short-chain fatty acids (acetic, butyric, and propionic acids) in cecum content were counted. Differences in the colon damage scores were observed; P. edulis peel intake improved serum antioxidant status. In the treatment protocol, decreased colon lipid peroxidation, a decreased number of aerobic bacteria and enterobacteria, and an improvement in acetic and butyric acid levels in the feces were observed. An improvement in the bifidobacteria and lactobacilli was observed in the prevention protocol. These results suggested that P. edulis peel can modulate microbiota and could be used as source of fiber and polyphenols in the prevention of oxidative stress through the improvement of serum and tissue antioxidant status.

Study Type : Animal Study

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