Patients with antibiotic-associated diarrhea secondary to pneumonia benefit from zinc supplementation of probiotic treatment. - GreenMedInfo Summary

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Abstract Title:

Effects of Zinc Combined with Probiotics on Antibiotic-associated Diarrhea Secondary to Childhood Pneumonia.

Abstract Source:

J Trop Pediatr. 2018 Dec 6. Epub 2018 Dec 6. PMID: 30521044

Abstract Author(s):

Rong Xiang, Qing Tang, Xiu-Qi Chen, Mu-Yan Li, Mei-Xiong Yang, Xiang Yun, Li Huang, Qing-Wen Shan

Article Affiliation:

Rong Xiang

Abstract:

Aim: The aim of this study was to evaluate the impact of zinc combined with probiotics (Bifico) on antibiotic-associated diarrhea (AAD) secondary to pneumonia.

Methods: A total of 50 patients with AAD secondary to pneumonia were randomly divided into a probiotics group (Bifico) and a combined group (zinc combined with Bifico) and 25 pneumonia patients without AAD as the control group. Serum levels of zinc, diamine oxidase (DAO) activity, D-lactate and intestinal flora [Bifidobacterium, Escherichia coli and Bifidobacterium/E. coli (B/E) ratio] were detected before and after intervention.

Results: The results showed that zinc combined with Bifico had significantly higher overall efficiency than Bifico alone for treatment of AAD secondary to pneumonia. Notably, the combined treatment increased the population of Bifidobacterium, while the number of E. coli was reduced, the B/E value was improved and DAO activity and D-lactate levels were markedly reduced.

Conclusion: Patients with AAD secondary to pneumonia benefit from zinc supplementation of probiotic treatment.

Article Published Date : Dec 05, 2018
Study Type : Human Study
Additional Links
Substances : Probiotics : CK(7680) : AC(1617), Zinc : CK(1940) : AC(339)
Diseases : Diarrhea: Antibiotic-Associated : CK(188) : AC(27)
Pharmacological Actions : Gastrointestinal Agents : CK(3145) : AC(1960)

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Key Research Topics

Substance

Zinc
Probiotics

Pharmacological Actions

Gastrointestinal Agents

Disease

Diarrhea: Antibiotic-Associated

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