n/a
Abstract Title:

Characterization of peptides from common bean protein isolates and their potential to inhibit markers of type-2 diabetes, hypertension and oxidative stress.

Abstract Source:

J Sci Food Agric. 2017 Jun ;97(8):2401-2410. Epub 2016 Oct 29. PMID: 27664971

Abstract Author(s):

Luis Mojica, Diego A Luna-Vital, Elvira González de Mejía

Article Affiliation:

Luis Mojica

Abstract:

BACKGROUND: Diabetes and hypertension are diseases affecting a high proportion of the world population; the use of food-based products such as common bean peptides may contribute to reduce the risk of complications associated to chronic diseases. The aim was to produce and characterize peptides from common bean protein isolates and evaluate their potential to inhibit markers of type-2 diabetes, hypertension and oxidative stress.

RESULTS: Mexican black and Brazilian Carioca bean isolated proteins were characterized after pepsin/pancreatin digestion. Also, four synthesized pure peptides, originally found in these beans, were evaluated. Bean protein digests and pure peptides exerted dipeptidyl peptidase-IV (DPP-IV) inhibition (IC= 0.03-0.87 mg dry weight (DW) mL). Lineweaver-Burk plots and computational modeling showed competitive inhibition of DPP-IV. Angiotensin-converting enzyme (ACE) inhibition ranged from IC= 0.09 to 0.99 mg DW mL, andα-glucosidase inhibition ranged from 36.3 to 50.1% mgDW. Carioca Perola bean digested proteins presented the highest antioxidant capacity (269.3 mmol LTrolox equivalent gDW) as the peptide KTYGL (P>0.05) with the most potent DPP-IV and ACE inhibition.

CONCLUSION: Peptides from common bean have antidiabetic and antihypertensive potential regardless of their antioxidant capacity.© 2016 Society of Chemical Industry.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.