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Abstract Title:

Personal exposure to fine particulate matter and blood pressure: Variations by particulate sources.

Abstract Source:

Chemosphere. 2021 Oct ;280:130602. Epub 2021 Apr 27. PMID: 34162067

Abstract Author(s):

Xiaoning Lei, Renjie Chen, Weihua Li, Zhen Cheng, Hongli Wang, Steven Chillrud, Beizhan Yan, Zhekang Ying, Jing Cai, Haidong Kan

Article Affiliation:

Xiaoning Lei

Abstract:

Fine particulate matter (PM) is a complex mixture of components which has been associated with various cardiovascular effects, such as elevated blood pressure (BP). However, evidences on specific sources behind these effects remain uncertain. Based on 140 72-h personal measurements among a panel of 36 health college students in Shanghai, China, we assessed associations between source-apportioned PMexposure and BP changes. Based on personal filter samples, PMsource apportionment was conducted using Positive Matrix Factorization (PMF) model. Linear mixed-effects models were applied to evaluate associations of source-specific PMexposure with BP changes. Seven sources were identified in PMF analysis. Among them, secondary sulfate (41%) and nitrate (24%) sources contributed most to personal PM, followed by industrial emissions (15%), traffic-related source (10%), coal combustion (6.2%), dust (2.4%) and aged sea salt (1.1%). We found nitrate, traffic-related source and coal combustion were significantly associated with increased BP. For example, an interquartile range increase in PMfrom traffic-related source was significantly associated with increase in systolic BP [1.5 (95% CI: 0.26, 2.7) mmHg], diastolic BP [1.2 (95% CI: 0.10, 2.2) mmHg] and mean arterial pressure [1.2 (95% CI: 0.15, 2.2) mmHg]. This is the first investigation linking personal PMsource profile and BP changes. This study provides evidence that several anthropogenic emissions (especially traffic-related emission) may be particularly responsible for BP increases, and highlights that the importance of development of health-oriented PMsource control strategies.

Study Type : Human Study

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