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Abstract Title:

The pharmacological activity of berberine, a review for liver protection.

Abstract Source:

Eur J Pharmacol. 2020 Oct 14:173655. Epub 2020 Oct 14. PMID: 33068590

Abstract Author(s):

Mengting Zhou, Ying Deng, Meichen Liu, Li Liao, Xuyang Dai, Chaocheng Guo, Xingtao Zhao, Linfeng He, Cheng Peng, Yunxia Li

Article Affiliation:

Mengting Zhou

Abstract:

Liver plays an important role in bile synthesis, metabolic function, degradation of toxins, new substances synthesis in body. However, hepatopathy morbidity and mortality are increasing year by year around the world, which become a major public health problem. Traditional Chinese medicine (TCM) has a prominent role in the treatment of liver diseases due to its definite curative effect and small side effects. The hepatoprotective effect of berberine has been extensively studied, so we comprehensively summarize the pharmacological activities of lipid metabolism regulation, bile acid adjustment, anti-inflammation, oxidation resistance, anti-fibrosis and anti-cancer and so on. Besides, the metabolism and toxicity of berberine and its new formulations to improve its effectiveness are expounded, providing a reference for the safe and effective clinical use of berberine.

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