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Article Publish Status: FREE
Abstract Title:

Grown on Germinated Brown Rice Inhibits IgE-Mediated Allergic Activity through the Suppression of FcRI-Dependent Signaling Pathwayand.

Abstract Source:

Evid Based Complement Alternat Med. 2019 ;2019:1485015. Epub 2019 Nov 29. PMID: 31871471

Abstract Author(s):

Ha-Kyoung Kwon, Hye-Jin Park

Article Affiliation:

Ha-Kyoung Kwon

Abstract:

(PL) has been used as a traditional herbal medicine owing to its immune regulatory activity. Previous studies reported that PL grown on germinated brown rice (PBR) exerted immunomodulatory, anticancer, and anti-inflammatory activities. However, role of PBR on type I hypersensitive reactions has not been studied yet. We found that PBR contained more polyphenolic compounds than PL extract. Among fractions, PBR butanol fraction (PBR-BuOH) significantly contained the most amounts of total polyphenolic contents compared with all extracts or fractions. In this study, anti-allergic activity of PBR-BuOH was examined usingandmodels of immunoglobulin E/antigen- (IgE/Ag-) stimulated allergy. The inhibitory activity of degranulation was higher in PBR-BuOH (IC41.31 ± 0.14 g/mL) than in PL-BuOH (IC108.07 ± 8.98 g/mL). We observed that PBR-BuOH suppressed calcium influx and the level of TNF-and IL-4 mRNA expression in a dose-dependent manner. The phosphorylation of Fyn, Gab2, PI3K, Syk, and IB protein is reduced by PBR-BuOH. Oral administration of PBR-BuOH inhibited allergic reactions including the extravasation of Evans blue dye, ear swelling, and infiltration of immune cells in mice with passive cutaneous anaphylaxis (PCA). These findings suggest that PBR-BuOH might be used as a functional food, a health supplement, or a drug for preventing type I hypersensitive allergic disease.

Study Type : Animal Study, In Vitro Study

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