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Abstract Title:

Phenolic-rich smoothie consumption ameliorates non-alcoholic fatty liver disease in obesity mice by increasing antioxidant response.

Abstract Source:

Chem Biol Interact. 2021 Feb 25 ;336:109369. Epub 2021 Jan 7. PMID: 33422521

Abstract Author(s):

Fernanda Torres Quitete, Giulia Medeiros Almeida Santos, Leilson de Oliveira Ribeiro, Cristiane Aguiar da Costa, Suely Pereira Freitas, Virgínia Martins da Matta, Julio Beltrame Daleprane

Article Affiliation:

Fernanda Torres Quitete

Abstract:

Consumption of foods rich in phenolic compounds can be beneficial for health. This study aimed to examine whether the consumption of a phenolic-rich smoothie, based on juçara, strawberry and banana, ameliorates metabolic status and liver damage of diet-induced obese mice. Forty male C57BL/6J mice were assigned into four groups (n = 10) and fed control diet with free access to water (C) or phenolic-rich smoothie (C-S), or fed high-fat diet with free access to water (HF) or phenolic-rich smoothie (HF-S) for five weeks. HF and HF-S groups had higher body weight gains than the C group, however the HF had a greater adipose index, higher plasma levels of glucose, insulin and leptin, as well as higher plasma and hepatic steatosis than C, C-S and HF-S groups. The liver oxidative stress markers were reduced in C-S and HF-S groups and the activity of catalase and glutathione peroxidase were higher compared with their counterparts. The present study suggests that regular consumption of a phenolic-rich smoothie improves the liver antioxidant status, prevents metabolic disorders and ameliorates non-alcoholic fatty liver disease caused by high-fat diet consumption.

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