Abstract Title:

Phenylethyl cinnamides: a new series of alpha-glucosidase inhibitors from the leaves of Aegle marmelos.

Abstract Source:

Bioorg Med Chem Lett. 2008 Sep 15 ;18(18):4956-8. Epub 2008 Aug 14. PMID: 18760601

Abstract Author(s):

Preecha Phuwapraisirisan, Thanchanok Puksasook, Jonkolnee Jong-Aramruang, Udom Kokpol

Article Affiliation:

Preecha Phuwapraisirisan


A series of phenylethyl cinnamides, which included new compounds named anhydromarmeline, aegelinosides A and B, were isolated from Aegle marmelos leaves as alpha-glucosidase inhibitors. The structures of new compounds were characterized by spectroscopic data and chemical degradation. Of compounds isolated, anhydroaegeline revealed the most potent inhibitory effect against alpha-glucosidase with IC(50) value of 35.8 microM. The present result also supports ethnopharmacological use of A. marmelos as a remedy for diabetes mellitus.

Study Type : In Vitro Study

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