n/a
Article Publish Status: FREE
Abstract Title:

Photobiomodulation Therapy in Cancer Patients with Mucositis: A Clinical Evaluation.

Abstract Source:

Photobiomodul Photomed Laser Surg. 2019 Mar ;37(3):142-150. Epub 2019 Feb 20. PMID: 31050952

Abstract Author(s):

Sérgio Luiz Pinheiro, Ana Cláudia Bonadiman, Ana Luiza Dos Anjos Borges Lemos, Bruna Maki Annicchino, Bruna Segatti, Daniel Sartorelli Pucca, Priscila Tessaro Dutra, Roberta Mariano de Carvalho E Silva, Frederico Leal

Article Affiliation:

Sérgio Luiz Pinheiro

Abstract:

To evaluate the use of photobiomodulation therapy (PBM-T) in patients undergoing chemotherapy and/or radiotherapy and affected by oral mucositis (OM).Few clinical studies have evaluated PBM-T, particularly in combination with photodynamic therapy (PDT), for the treatment of OM.Thirty-one patients were divided by convenience into two groups. One received PBM-T ( = 17) alone, consisting of low-intensity laser (LIL) irradiation (wavelength 660 nm, continuous mode, spot energy 4 J, energy density 142 J/cm, irradiation time 40 s per spot), once weekly for 4 weeks. The other ( = 14) received a combination of PBM-T and PDT, with curcumin as photosensitizer. Patients were instructed to rinse their mouth with 20 mL of curcumin solution for 5 min. The oral cavity was irradiated with a blue light-emitting diode (power 1200 mV, wavelength 468 nm) for 5 min. LIL was applied as in the PBM-T group. After treatment, OM severity was reassessed. The results were analyzed by the Wilcoxon and Mann-Whitney tests.Both PBM-T alone and PBM-T+PDT yielded significant reductions in OM grade ( < 0.01). PDT+PBM-T resulted in a significantly shorter healing time compared with PBM-T alone ( = 0.0321).Within the parameters of this study, PBM-T+PDT was an effective method to accelerate the OM healing process.

Study Type : Human Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.