n/a
Abstract Title:

Phthalide dimers from Angelica sinensis and their COX-2 inhibition activity.

Abstract Source:

Fitoterapia. 2018 Sep ;129:102-107. Epub 2018 Jun 21. PMID: 29935258

Abstract Author(s):

Jie-Li Lv, Lai-Bin Zhang, Li-Min Guo

Article Affiliation:

Jie-Li Lv

Abstract:

Four new dimeric phthalides, angesinenolides C-F (1-4), along with three known ones, were isolated from the roots of Angelica sinensis. Their structures were determined by means of HRMS and NMR experiments. The structures of compounds 1 and 3 were confirmed using X-ray crystallographic data. All isolated compounds were tested for activities on the inhibition of COX-2 enzyme in vitro. Compounds 1-6 exhibited inhibitory activity against COX-2 with ICvalues ranging from 29.32 ± 0.07 to 137.91 ± 0.24 μM.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.