Abstract Title:

Physical Activity Counteracts Tumor Cell Growth in Colon Carcinoma C26-Injected Muscles: An Interim Report.

Abstract Source:

Eur J Transl Myol. 2016 Jun 13 ;26(2):5958. Epub 2016 Jun 13. PMID: 27478560

Abstract Author(s):

Charlotte Hiroux, Tijs Vandoorne, Katrien Koppo, Stefan De Smet, Peter Hespel, Emanuele Berardi

Article Affiliation:

Charlotte Hiroux

Abstract:

Skeletal muscle tissue is a rare site of tumor metastasis but is the main target of the degenerative processes occurring in cancer-associated cachexia syndrome. Beneficial effects of physical activity in counteracting cancer-related muscle wasting have been described in the last decades. Recently it has been shown that, in tumor xeno-transplanted mouse models, physical activity is able to directly affect tumor growth by modulating inflammatory responses in the tumor mass microenvironment. Here, we investigated the effect of physical activity on tumor cell growth in colon carcinoma C26 cells injected tibialis anterior muscles of BALB/c mice. Histological analyses revealed that 4 days of voluntary wheel running significantly counteracts tumor cell growth in C26-injected muscles compared to the non-injected sedentary controls. Since striated skeletal muscle tissue is the site of voluntary contraction, our results confirm that physical activity can also directly counteract tumor cell growth in a metabolically active tissue that is usually not a target for metastasis.

Study Type : Animal Study
Additional Links
Therapeutic Actions : Exercise : CK(2795) : AC(411)
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450)

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