Abstract Title:

Acupuncture for a first episode of acute ischaemic stroke: an observer-blinded randomised controlled pilot study.

Abstract Source:

Acupunct Med. 2016 Apr 19. Epub 2016 Apr 19. PMID: 27095698

Abstract Author(s):

Ching-Hsiung Liu, Yu-Ting Hsieh, Hung-Pin Tseng, Hung-Chih Lin, Chun-Liang Lin, Tai-Yi Wu, Shu-Hua Lin, Szu-Hung Tsao, Hong Zhang

Article Affiliation:

Ching-Hsiung Liu


OBJECTIVE: To determine the required sample size for, and feasibility of, a RCT examining the effectiveness of early acupuncture for acute ischaemic stroke.

METHODS: Thirty-eight patients aged 40-85 years with a first episode of acute ischaemic stroke presenting within 72 h of stroke onset were randomly assigned to receive manual acupuncture (MA group; n=20) plus standard care or standard care only (control group, n=18). The acupuncture treatment was provided daily for 2 weeks. The primary outcome was the change in the National Institutes of Health Stroke Scale (NIHSS) score between baseline and 4 weeks. Secondary outcomes included changes in the Fugl-Meyer assessment (FMA) and the functional independence measure scores between baseline and 4 weeks, and changes in NIHSS, Barthel Index and modified Rankin Scale scores at 12 weeks.

RESULTS: Thirty-one patients completed the study (dropout rate=18%) and adverse effects were minimal. No significant differences were seen between groups in the improvements in NIHSS scores, although there tended to be a greater reduction in NIHSS score after 1 week in the MA group relative to the control group (p=0.066). The post-stroke motor activity at 4 weeks was associated with a significantly increased FMA score in the acupuncture group compared with the control group (p<0.05), but not supported by intergroup analysis.

CONCLUSIONS: This pilot study indicates that acupuncture appears to be safe for patients in the acute stage of ischaemic stroke. A subsequent trial with a larger sample size (estimated at n=122) is required to confirm whether early acupuncture intervention contributes to earlier functional improvement and to assess the longer-term clinical efficacy of acupuncture.


Study Type : Human Study
Additional Links
Therapeutic Actions : Acupuncture : CK(3141) : AC(370)

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Sayer Ji
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