Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus.
Antimicrob Agents Chemother. 2006 Feb;50(2):810-2. PMID: 16436753
Full Citation: "Piperine, a trans-trans isomer of 1-piperoyl-piperidine, in combination with ciprofloxacin markedly reduced the MICs and mutation prevention concentration of ciprofloxacin for Staphylococcus aureus, including methicillin-resistant S. aureus. The enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIPr-1) strains in the presence of piperine suggest its involvement in the inhibition of bacterial efflux pumps."