Abstract Title:

Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus.

Abstract Source:

Antimicrob Agents Chemother. 2006 Feb;50(2):810-2. PMID: 16436753

Abstract Author(s):

Inshad Ali Khan, Zahid Mehmood Mirza, Ashwani Kumar, Vijeshwar Verma, Ghulam Nabi Qazi


Full Citation: "Piperine, a trans-trans isomer of 1-piperoyl-piperidine, in combination with ciprofloxacin markedly reduced the MICs and mutation prevention concentration of ciprofloxacin for Staphylococcus aureus, including methicillin-resistant S. aureus. The enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIPr-1) strains in the presence of piperine suggest its involvement in the inhibition of bacterial efflux pumps."

Study Type : In Vitro Study

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