Article Publish Status: FREE
Abstract Title:

Pistachio Consumption Prevents and Improves Lipid Dysmetabolism by Reducing the Lipid Metabolizing Gene Expression in Diet-Induced Obese Mice.

Abstract Source:

Nutrients. 2018 Dec 1 ;10(12). Epub 2018 Dec 1. PMID: 30513740

Abstract Author(s):

Simona Terzo, Gaetano Felice Caldara, Vincenzo Ferrantelli, Roberto Puleio, Giovanni Cassata, Flavia Mulè, Antonella Amato

Article Affiliation:

Simona Terzo


Pistachios contain beneficial substances such as unsaturated fatty acids, phytosterols, and polyphenols. In the present study, we investigated if pistachio consumption is able to prevent or to revert hyperglycemia, dyslipidemia, hepatic steatosis, and adipose tissue morphological alterations caused by high fat diet (HFD) in the mouse. Moreover, the impact of pistachio intake on the mRNA expression of peroxisome proliferator-activated receptorγ (), fatty acid transport proteins (), fatty acid synthase (), stearoyl-CoA desaturase (), and sterol regulatory element-binding transcription factor-1c () in liver and adipose tissue was also analyzed. No change in body weight, food intake, and hyperglycemia was observed between mice consuming pistachios (HFD-P) and HFD mice. Pistachio intake was able to prevent but not to reverse HFD-induced hypertriglyceridemia. Cholesterol plasma levels, steatosis grading, body fat mass, and adipocyte size were significantly lower in HFD-P group compared to HFD in both prevention and reversal protocol. Pistachio-diet was able to prevent HFD-induced overexpression of,, andin the liver and, andin adipose tissue. Similarly, HFD-P significantly ameliorated the expression levels ofandin the liver and, andin adipose tissue of obese mice. The present study shows that pistachio consumption is able to prevent and to ameliorate obesity-related dysfunctions by positively modulating the expression of genes linked to lipid metabolism.

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