Abstract Title:

Modulation of Cholesterol-Related Gene Expression by Dietary Fiber Fractions from Edible Mushrooms.

Abstract Source:

J Agric Food Chem. 2015 Aug 26 ;63(33):7371-80. Epub 2015 Aug 18. PMID: 26284928

Abstract Author(s):

Víctor Caz, Alicia Gil-Ramírez, Carlota Largo, María Tabernero, Mónica Santamaría, Roberto Martín-Hernández, Francisco R Marín, Guillermo Reglero, Cristina Soler-Rivas

Article Affiliation:

Víctor Caz

Abstract:

Mushrooms are a source of dietary fiber (DF) with a cholesterol-lowering effect. However, their underlying mechanisms are poorly understood. The effect of DF-enriched fractions from three mushrooms species on cholesterol-related expression was studied in vitro. The Pleurotus ostreatus DF fraction (PDF) was used in mice models to assess its potential palliative or preventive effect against hypercholesterolemia. PDF induced a transcriptional response in Caco-2 cells, suggesting a possible cholesterol-lowering effect. In the palliative setting, PDF reduced hepatic triglyceride likely because Dgat1 was downregulated. However, cholesterol-related biochemical data showed no changes and no relation with the observed transcriptional modulation. In the preventive setting, PDF modulated cholesterol-related genes expression in a manner similar to that of simvastatin and ezetimibe in the liver, although no changes in plasma and liver biochemical data were induced. Therefore, PDF may be useful reducing hepatic triglyceride accumulation. Because it induced a molecular response similar to hypocholesterolemic drugs in liver, further dose-dependent studies should be carried out.

Study Type : In Vitro Study

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