Article Publish Status: FREE
Abstract Title:

Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine.

Abstract Source:

Evid Based Complement Alternat Med. 2015 ;2015:823178. Epub 2015 Apr 7. PMID: 25945113

Abstract Author(s):

Jutamas Saengsai, Sumonthip Kongtunjanphuk, Nuttawan Yoswatthana, Tanawan Kummalue, Weena Jiratchariyakul

Article Affiliation:

Jutamas Saengsai

Abstract:

Plumericin, an iridoid lactone, was isolated with relatively high yield from Momordica charantia vine using the supercritical fluid extraction (SFE) and the separation box (Sepbox) comprising dual combination of high-performance liquid chromatography and solid phase extraction. This compound showed antibacterial activity against Enterococcus faecalis and Bacillus subtilis with minimum inhibitory concentration (MIC) values better than cloxacillin. Plumericin potently inhibited proliferation of two leukemic cancer cell lines: they were acute and chronic leukemic cancer cell lines, NB4 and K562, with the effective doses (ED50) of 4.35± 0.21 and 5.58 ± 0.35 μg/mL, respectively. In addition, the mechanism of growth inhibition in both cell lines was induced by apoptosis, together with G2/M arrest in K562 cells.

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