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Article Publish Status: FREE
Abstract Title:

Polyphenol Extract ofLeaves Alleviates Colonic Inflammation in Dextran Sulfate Sodium-Treated Mice.

Abstract Source:

Evid Based Complement Alternat Med. 2020 ;2020:6295402. Epub 2020 Nov 24. PMID: 33299453

Abstract Author(s):

Yunjuan Zhang, Lei Peng, Wenyun Li, Tianyi Dai, Long Nie, Jing Xie, Yu Ai, Lingfei Li, Yang Tian, Jun Sheng

Article Affiliation:

Yunjuan Zhang

Abstract:

Lam. is an essential herb used for the treatment of inflammation, diabetes, high blood pressure, and other diseases. In this study, phenolic extracts ofleaves were obtained and analyzed. The results showed that the main identifiable phenols were astragalin, chlorogenic acid, isoquercitrin, kaempferitrin, luteolin, quercetin, and rutin. The effects ofpolyphenol extract (MOPE) on experimental colitis induced by 3% dextran sulfate sodium (DSS) were investigated. The results showed that oral administration of MOPE significantly alleviated the symptoms of DSS-induced colitis. MOPE significantly reduced weight loss, the disease activity index, colon shortening, and mucosal damage. In addition, MOPE attenuated the infiltration of CD3T cells, CD177neutrophils, and F4/80macrophages and significantly inhibited the secretion of IL-6 and TNF-. After the MOPE administration, the expression of proteins associated with the NF-B signaling pathway changed. Specifically, compared with that of the DSS group, the protein expression of NF-Band p-IBwas downregulated, and the expression of IBwas upregulated. This study revealed the anti-inflammatory effects and mechanisms of MOPE in the colon, indicating its potential use in preventing inflammation-driven diseases.

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