Abstract Title:

Polyphenolic extract from extra virgin olive oil inhibits the inflammatory response in IL-1β-activated synovial fibroblasts.

Abstract Source:

Br J Nutr. 2018 Oct 26:1-8. Epub 2018 Oct 26. PMID: 30360768

Abstract Author(s):

María Ángeles Rosillo, Catalina Alarcón-de-la-Lastra, María Luisa Castejón, Tatiana Montoya, Marta Cejudo-Guillén, Marina Sánchez-Hidalgo

Article Affiliation:

María Ángeles Rosillo


The polyphenolic extract (PE) from extra virgin olive oil (EVOO) has been shown to possess important anti-inflammatory and joint protective properties in murine models of rheumatoid arthritis (RA). This study was designed to evaluate the effects of PE on IL-1β-activated human synovial fibroblasts SW982 cell line. PE from EVOO treatment inhibited IL-1β-induced matrix metalloproteases (P<0·001), TNF-α and IL-6 production (P<0·001). Similarly, IL-1β-induced cyclo-oxygenase-2 and microsomal PGE synthase-1 up-regulations were down-regulated by PE (P<0·001). Moreover, IL-1β-induced mitogen-activated protein kinase (MAPK) phosphorylation and NF-κB activation were ameliorated by PE (P<0·001). These results suggest that PE from EVOO reduces the production of proinflammatory mediators in human synovial fibroblasts; particularly, these protective effects could be related to the inhibition of MAPK and NF-κB signalling pathways. Taken together, PE from EVOO probably could provide anattractive complement in management of diseases associated with over-activation of synovial fibroblasts, such as RA.

Study Type : In Vitro Study

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