polyphenols are able to modify epigenetic mechanisms promoting immune modulation - GreenMedInfo Summary
Modulation of immune function by polyphenols: possible contribution of epigenetic factors.
Nutrients. 2013 Jul ;5(7):2314-32. Epub 2013 Jun 28. PMID: 23812304
Several biological activities have been described for polyphenolic compounds, including a modulator effect on the immune system. The effects of these biologically active compounds on the immune system are associated to processes as differentiation and activation of immune cells. Among the mechanisms associated to immune regulation are epigenetic modifications as DNA methylation of regulatory sequences, histone modifications and posttranscriptional repression by microRNAs that influences the gene expression of key players involved in the immune response. Considering that polyphenols are able to regulate the immune function and has been also demonstrated an effect on epigenetic mechanisms, it is possible to hypothesize that there exists a mediator role of epigenetic mechanisms in the modulation of the immune response by polyphenols.