Abstract Title:

Anti-necrosis potential of polyphenols against snake venoms.

Abstract Source:

Planta Med. 1999 Apr;65(3):266-8. PMID: 19874222

Abstract Author(s):

Jiraporn Leanpolchareanchai, Pimolpan Pithayanukul, Rapepol Bavovada

Article Affiliation:

Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.


Polyphenols from the extracts of Areca catechu L. and Quercus infectoria Oliv. inhibited phospholipase A(2), proteases, hyaluronidase and L-amino acid oxidase of Naja naja kaouthia Lesson (NK) and Calloselasma rhodostoma Kuhl (CR) venoms by in vitro tests. Both extracts inhibited the hemorrhagic activity of CR venom and the dermonecrotic activity of NK venom by in vivo tests. The inhibitory activity of plant polyphenols against local tissue necrosis induced by snake venoms may be caused by inhibition of inflammatory reactions, hemorrhage, and necrosis. The result implies the therapeutic potential of plant polyphenols against necrosis in snakebite victims.

Study Type : Commentary

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