Polyphenols from the medical mushroom Phellinus baumii inhibited H1N1, H5N1, and H3N2 neuraminidase activity. - GreenMedInfo Summary
Abstract Title:
Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii.
Abstract Source:
Bioorg Med Chem Lett. 2015 Aug 15 ;25(16):3256-60. Epub 2015 May 31. PMID: 26077494
Article Affiliation:
Byung Soon Hwang
Abstract:
Five polyphenols were isolated from the ethanolic extract of the fruiting bodies of Phellinus baumii. These compounds were identified by various spectroscopic methods as hispidin, hypholomine B, inoscavin A, davallialactone, and phelligridin D. All compounds inhibited noncompetitively H1N1, H5N1, and H3N2 neuraminidase activity and reduced the amount of virally-induced cytopathic effect (CPE) according to an MDCK cell-based assay.
Article Published Date : Aug 14, 2015
Study Type : In Vitro Study
Additional Links
Substances : Medicinal Mushrooms : CK(1715) : AC(797), Mushrooms: All : CK(1716) : AC(798), Polyphenols : CK(1878) : AC(700)
Diseases : H3N2 Infection : CK(19) : AC(9), H5N1 Infection : CK(10) : AC(8), Influenza A : CK(534) : AC(169)
Pharmacological Actions : Neurominidase Inhibitor : CK(20) : AC(19)
